By Clifford J Rosen; American Society for Bone and Mineral Research
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The Wnt/β-catenin, Hh, and BMP pathways signaling are all important in chondrocyte survival. 10 Molecular, Cellular, and Genetic Determinants of Bone Structure and Formation (A) P D using endogenous cells, autologous cells and tissues, or iPS (induced pleuripotent stem) cells. Understanding skeletal development is also indispensable for understanding pathological mechanisms in skeletal diseases, ﬁnding therapeutic targets, promoting consistent cartilage or bone repair in vivo and eventually growing functional cartilage or bone in vitro.
Somite formation and patterning. Int Rev Cytol 198: 1–65. 7. Scaal M, Christ B. 2004. Formation and differentiation of the avian dermomyotome. Anat Embryol (Berl) 208(6): 411–424. 8. Aulehla A, Pourquie O. 2006. On periodicity and directionality of somitogenesis. Anat Embryol (Berl) 211(Suppl 1): 3–8. 9. Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquie O. 2006. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 314(5805): 1595–1598.
Dev cell 13(2): 298–304. Skeletal Morphogenesis and Embryonic Development 11 15. Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y. 2009. Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PloS One 4(5): e5603. 16. Goldbeter A, Pourquie O. 2008. Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol 252(3): 574–585.