Diseases and disorders of mineral metabolism by Clifford J Rosen; American Society for Bone and Mineral

By Clifford J Rosen; American Society for Bone and Mineral Research

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The Wnt/β-catenin, Hh, and BMP pathways signaling are all important in chondrocyte survival. 10 Molecular, Cellular, and Genetic Determinants of Bone Structure and Formation (A) P D using endogenous cells, autologous cells and tissues, or iPS (induced pleuripotent stem) cells. Understanding skeletal development is also indispensable for understanding pathological mechanisms in skeletal diseases, finding therapeutic targets, promoting consistent cartilage or bone repair in vivo and eventually growing functional cartilage or bone in vitro.

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Dev cell 13(2): 298–304. Skeletal Morphogenesis and Embryonic Development 11 15. Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y. 2009. Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PloS One 4(5): e5603. 16. Goldbeter A, Pourquie O. 2008. Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol 252(3): 574–585.

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